T3 · RareMeta · C-TierEvolutionExplosion

Brotato Exothermic Reaction

Tier 3 item · 2 builds in our database

Exothermic Reaction causes evolved enemies to have a 33% chance to explode upon death, dealing 10 damage plus an additional 100% if they are evolved. This item excels in builds that focus on defeating evolved enemies quickly.

Item Stats

Evolved (mecha and mutated) enemies have a 33% chance to explode for 10 (+100% Evolution) damage when they die—
Dodge-4 %

Meta Usage

tracked builds (curated + per-character meta) include Exothermic Reaction

Auto-Tier

From usage frequency across our build pool, weighted by difficulty

Top characters

Most often: Mad Scientist

When to buy Exothermic Reaction

Pick Exothermic Reaction if you're facing many evolved enemies or if you're running a build that leverages high damage output and enemy evolution. It's particularly effective with characters that can boost their damage or have high Engineering for additional synergy.

When to skip Exothermic Reaction

Skip this item if your build relies on dodging or has low damage output, as the -4% Dodge could hinder your survivability. Characters that do not benefit from enemy explosions may also want to avoid it.

Items most often combined with Exothermic Reaction

Calculated from 2 builds in our database that ship Exothermic Reaction. Higher % = more consistent synergy.

Best characters for Exothermic Reaction

Characters that pick up Exothermic Reaction in our curated build pool — with notes on why the combo works where we have them.

Mad Scientist

1 build

Turns evolved Mecha and Mutant enemies into bombs whose damage scales directly with Evolution, perfectly matching Mad Scientist’s gameplan of forcing many positive Evolution changes.

Variant

1 build

Turns Evolution into area damage: as you raise Evolution, evolved enemies effectively nuke their neighbors on death. This is extremely strong on dense jungle waves and synergizes well with ranged builds and other explosive tools.