T3 · RareMeta · A-TierHarvesting

Brotato Blood Donation

Tier 3 item · 17 builds in our database

Blood Donation increases your Harvesting by 40 but inflicts 1 damage per second without granting invulnerability. This item is useful for builds focused on maximizing resource gain while managing health carefully.

Item Stats

HarvestingYou take 1 damage per second (does not give invulnerability time)+40

Meta Usage

tracked builds (curated + per-character meta) include Blood Donation

Auto-Tier

From usage frequency across our build pool, weighted by difficulty

Top characters

Most often: Masochist

When to buy Blood Donation

Consider Blood Donation if you're playing characters like Ranger or Wildling that can benefit from high Harvesting. It's particularly effective when paired with items that mitigate health loss or enhance resource collection.

When to skip Blood Donation

Skip this item if you're using characters that struggle with health management or if your build lacks healing options, as the constant damage can be detrimental.

Items most often combined with Blood Donation

Calculated from 17 builds in our database that ship Blood Donation. Higher % = more consistent synergy.

Best characters for Blood Donation

Characters that pick up Blood Donation in our curated build pool — with notes on why the combo works where we have them.

Bull

3 builds

Blood Donation is called out as crucial because it lets Bull trigger explosions without needing enemies to hit him, effectively turning self-damage into constant AoE while also giving strong harvesting.

Masochist

4 builds

Blood Donation adds passive self-damage that constantly triggers Masochist’s damage bonus while also giving strong Harvesting to scale your economy. With Masochist’s huge HP Regeneration and Armor, the self-damage is manageable and becomes a damage engine.

Wildling

2 builds

Wildling’s huge lifesteal with Primitive weapons makes the self-damage from Blood Donation almost trivial, turning it into a free Harvesting engine that scales your economy and power over time, especially in Endless runs.